Absence of kelch13 artemisinin resistance markers but strong selection for lumefantrine-tolerance molecular markers following 18 years of artemisinin-based combination therapy use in Mpumalanga Province, South Africa (2001–2018)
Identifieur interne : 000B21 ( Main/Exploration ); précédent : 000B20; suivant : 000B22Absence of kelch13 artemisinin resistance markers but strong selection for lumefantrine-tolerance molecular markers following 18 years of artemisinin-based combination therapy use in Mpumalanga Province, South Africa (2001–2018)
Auteurs : Jaishree Raman [Afrique du Sud] ; Frank M. Kagoro [Afrique du Sud, Thaïlande] ; Aaron Mabuza [Afrique du Sud] ; Gillian Malatje ; Anthony Reid [Luxembourg (pays)] ; John Frean [Afrique du Sud] ; Karen I. Barnes [Afrique du Sud]Source :
- Malaria Journal [ 1475-2875 ] ; 2019.
Abstract
The ability of
Molecular analyses to determine the prevalence of alleles associated with resistance to lumefantrine (
Parasite DNA was successfully amplified from 1667/2393 (70%) of malaria-positive rapid diagnostic tests routinely collected at primary health care facilities. No artemisinin resistance-associated
No
Url:
DOI: 10.1186/s12936-019-2911-y
PubMed: 31438951
PubMed Central: 6704579
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000127
- to stream Pmc, to step Curation: 000127
- to stream Pmc, to step Checkpoint: 000A45
- to stream Ncbi, to step Merge: 000952
- to stream Ncbi, to step Curation: 000952
- to stream Ncbi, to step Checkpoint: 000952
- to stream Main, to step Merge: 000B21
- to stream Main, to step Curation: 000B21
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Absence of <italic>kelch13</italic> artemisinin resistance markers but strong selection for lumefantrine-tolerance molecular markers following 18 years of artemisinin-based combination therapy use in Mpumalanga Province, South Africa (2001–2018)</title><author><name sortKey="Raman, Jaishree" sort="Raman, Jaishree" uniqKey="Raman J" first="Jaishree" last="Raman">Jaishree Raman</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0630 4574</institution-id><institution-id institution-id-type="GRID">grid.416657.7</institution-id><institution>Centre for Emerging Zoonotic and Parasitic Diseases, National Institute for Communicable Diseases,</institution><institution>A Division of the National Health Laboratory Service,</institution></institution-wrap>Sandringham, Johannesburg, Gauteng South Africa</nlm:aff><wicri:noCountry code="subfield">Gauteng South Africa</wicri:noCountry></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1937 1135</institution-id><institution-id institution-id-type="GRID">grid.11951.3d</institution-id><institution>Wits Research Institute for Malaria,</institution><institution>Faculty of Health Sciences, University of Witwatersrand,</institution></institution-wrap>Johannesburg, South Africa</nlm:aff><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>Johannesburg</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2107 2298</institution-id><institution-id institution-id-type="GRID">grid.49697.35</institution-id><institution>UP Institute for Sustainable Malaria Control,</institution><institution>Faculty of Health Sciences, University of Pretoria,</institution></institution-wrap>Pretoria, South Africa</nlm:aff><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>Pretoria</wicri:regionArea></affiliation></author><author><name sortKey="Kagoro, Frank M" sort="Kagoro, Frank M" uniqKey="Kagoro F" first="Frank M." last="Kagoro">Frank M. Kagoro</name><affiliation wicri:level="1"><nlm:aff id="Aff4"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1937 1151</institution-id><institution-id institution-id-type="GRID">grid.7836.a</institution-id><institution>Division of Clinical Pharmacology, Department of Medicine,</institution><institution>University of Cape Town,</institution></institution-wrap>Cape Town, South Africa</nlm:aff><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>Cape Town</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff5"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 5936 4917</institution-id><institution-id institution-id-type="GRID">grid.501272.3</institution-id><institution>Mahidol-Oxford Tropical Medicine Research Unit,</institution></institution-wrap>Bangkok, Thailand</nlm:aff><country xml:lang="fr">Thaïlande</country><wicri:regionArea>Bangkok</wicri:regionArea></affiliation></author><author><name sortKey="Mabuza, Aaron" sort="Mabuza, Aaron" uniqKey="Mabuza A" first="Aaron" last="Mabuza">Aaron Mabuza</name><affiliation wicri:level="1"><nlm:aff id="Aff4"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1937 1151</institution-id><institution-id institution-id-type="GRID">grid.7836.a</institution-id><institution>Division of Clinical Pharmacology, Department of Medicine,</institution><institution>University of Cape Town,</institution></institution-wrap>Cape Town, South Africa</nlm:aff><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>Cape Town</wicri:regionArea></affiliation></author><author><name sortKey="Malatje, Gillian" sort="Malatje, Gillian" uniqKey="Malatje G" first="Gillian" last="Malatje">Gillian Malatje</name><affiliation><nlm:aff id="Aff6">Mpumalanga Provincial Malaria Elimination Programme, Nelspruit, Mpumalanga South Africa</nlm:aff><wicri:noCountry code="subfield">Mpumalanga South Africa</wicri:noCountry></affiliation></author><author><name sortKey="Reid, Anthony" sort="Reid, Anthony" uniqKey="Reid A" first="Anthony" last="Reid">Anthony Reid</name><affiliation wicri:level="1"><nlm:aff id="Aff7"><institution-wrap><institution-id institution-id-type="GRID">grid.452393.a</institution-id><institution>Operational Research Unit,</institution><institution>Médecins Sans Frontières, Operational Centre,</institution></institution-wrap>Brussels, Luxembourg</nlm:aff><country xml:lang="fr">Luxembourg (pays)</country><wicri:regionArea>Brussels</wicri:regionArea></affiliation></author><author><name sortKey="Frean, John" sort="Frean, John" uniqKey="Frean J" first="John" last="Frean">John Frean</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0630 4574</institution-id><institution-id institution-id-type="GRID">grid.416657.7</institution-id><institution>Centre for Emerging Zoonotic and Parasitic Diseases, National Institute for Communicable Diseases,</institution><institution>A Division of the National Health Laboratory Service,</institution></institution-wrap>Sandringham, Johannesburg, Gauteng South Africa</nlm:aff><wicri:noCountry code="subfield">Gauteng South Africa</wicri:noCountry></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1937 1135</institution-id><institution-id institution-id-type="GRID">grid.11951.3d</institution-id><institution>Wits Research Institute for Malaria,</institution><institution>Faculty of Health Sciences, University of Witwatersrand,</institution></institution-wrap>Johannesburg, South Africa</nlm:aff><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>Johannesburg</wicri:regionArea></affiliation></author><author><name sortKey="Barnes, Karen I" sort="Barnes, Karen I" uniqKey="Barnes K" first="Karen I." last="Barnes">Karen I. Barnes</name><affiliation wicri:level="1"><nlm:aff id="Aff4"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1937 1151</institution-id><institution-id institution-id-type="GRID">grid.7836.a</institution-id><institution>Division of Clinical Pharmacology, Department of Medicine,</institution><institution>University of Cape Town,</institution></institution-wrap>Cape Town, South Africa</nlm:aff><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>Cape Town</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">31438951</idno><idno type="pmc">6704579</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6704579</idno><idno type="RBID">PMC:6704579</idno><idno type="doi">10.1186/s12936-019-2911-y</idno><date when="2019">2019</date><idno type="wicri:Area/Pmc/Corpus">000127</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000127</idno><idno type="wicri:Area/Pmc/Curation">000127</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000127</idno><idno type="wicri:Area/Pmc/Checkpoint">000A45</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000A45</idno><idno type="wicri:Area/Ncbi/Merge">000952</idno><idno type="wicri:Area/Ncbi/Curation">000952</idno><idno type="wicri:Area/Ncbi/Checkpoint">000952</idno><idno type="wicri:Area/Main/Merge">000B21</idno><idno type="wicri:Area/Main/Curation">000B21</idno><idno type="wicri:Area/Main/Exploration">000B21</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Absence of <italic>kelch13</italic> artemisinin resistance markers but strong selection for lumefantrine-tolerance molecular markers following 18 years of artemisinin-based combination therapy use in Mpumalanga Province, South Africa (2001–2018)</title><author><name sortKey="Raman, Jaishree" sort="Raman, Jaishree" uniqKey="Raman J" first="Jaishree" last="Raman">Jaishree Raman</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0630 4574</institution-id><institution-id institution-id-type="GRID">grid.416657.7</institution-id><institution>Centre for Emerging Zoonotic and Parasitic Diseases, National Institute for Communicable Diseases,</institution><institution>A Division of the National Health Laboratory Service,</institution></institution-wrap>Sandringham, Johannesburg, Gauteng South Africa</nlm:aff><wicri:noCountry code="subfield">Gauteng South Africa</wicri:noCountry></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1937 1135</institution-id><institution-id institution-id-type="GRID">grid.11951.3d</institution-id><institution>Wits Research Institute for Malaria,</institution><institution>Faculty of Health Sciences, University of Witwatersrand,</institution></institution-wrap>Johannesburg, South Africa</nlm:aff><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>Johannesburg</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2107 2298</institution-id><institution-id institution-id-type="GRID">grid.49697.35</institution-id><institution>UP Institute for Sustainable Malaria Control,</institution><institution>Faculty of Health Sciences, University of Pretoria,</institution></institution-wrap>Pretoria, South Africa</nlm:aff><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>Pretoria</wicri:regionArea></affiliation></author><author><name sortKey="Kagoro, Frank M" sort="Kagoro, Frank M" uniqKey="Kagoro F" first="Frank M." last="Kagoro">Frank M. Kagoro</name><affiliation wicri:level="1"><nlm:aff id="Aff4"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1937 1151</institution-id><institution-id institution-id-type="GRID">grid.7836.a</institution-id><institution>Division of Clinical Pharmacology, Department of Medicine,</institution><institution>University of Cape Town,</institution></institution-wrap>Cape Town, South Africa</nlm:aff><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>Cape Town</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff5"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 5936 4917</institution-id><institution-id institution-id-type="GRID">grid.501272.3</institution-id><institution>Mahidol-Oxford Tropical Medicine Research Unit,</institution></institution-wrap>Bangkok, Thailand</nlm:aff><country xml:lang="fr">Thaïlande</country><wicri:regionArea>Bangkok</wicri:regionArea></affiliation></author><author><name sortKey="Mabuza, Aaron" sort="Mabuza, Aaron" uniqKey="Mabuza A" first="Aaron" last="Mabuza">Aaron Mabuza</name><affiliation wicri:level="1"><nlm:aff id="Aff4"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1937 1151</institution-id><institution-id institution-id-type="GRID">grid.7836.a</institution-id><institution>Division of Clinical Pharmacology, Department of Medicine,</institution><institution>University of Cape Town,</institution></institution-wrap>Cape Town, South Africa</nlm:aff><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>Cape Town</wicri:regionArea></affiliation></author><author><name sortKey="Malatje, Gillian" sort="Malatje, Gillian" uniqKey="Malatje G" first="Gillian" last="Malatje">Gillian Malatje</name><affiliation><nlm:aff id="Aff6">Mpumalanga Provincial Malaria Elimination Programme, Nelspruit, Mpumalanga South Africa</nlm:aff><wicri:noCountry code="subfield">Mpumalanga South Africa</wicri:noCountry></affiliation></author><author><name sortKey="Reid, Anthony" sort="Reid, Anthony" uniqKey="Reid A" first="Anthony" last="Reid">Anthony Reid</name><affiliation wicri:level="1"><nlm:aff id="Aff7"><institution-wrap><institution-id institution-id-type="GRID">grid.452393.a</institution-id><institution>Operational Research Unit,</institution><institution>Médecins Sans Frontières, Operational Centre,</institution></institution-wrap>Brussels, Luxembourg</nlm:aff><country xml:lang="fr">Luxembourg (pays)</country><wicri:regionArea>Brussels</wicri:regionArea></affiliation></author><author><name sortKey="Frean, John" sort="Frean, John" uniqKey="Frean J" first="John" last="Frean">John Frean</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0630 4574</institution-id><institution-id institution-id-type="GRID">grid.416657.7</institution-id><institution>Centre for Emerging Zoonotic and Parasitic Diseases, National Institute for Communicable Diseases,</institution><institution>A Division of the National Health Laboratory Service,</institution></institution-wrap>Sandringham, Johannesburg, Gauteng South Africa</nlm:aff><wicri:noCountry code="subfield">Gauteng South Africa</wicri:noCountry></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1937 1135</institution-id><institution-id institution-id-type="GRID">grid.11951.3d</institution-id><institution>Wits Research Institute for Malaria,</institution><institution>Faculty of Health Sciences, University of Witwatersrand,</institution></institution-wrap>Johannesburg, South Africa</nlm:aff><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>Johannesburg</wicri:regionArea></affiliation></author><author><name sortKey="Barnes, Karen I" sort="Barnes, Karen I" uniqKey="Barnes K" first="Karen I." last="Barnes">Karen I. Barnes</name><affiliation wicri:level="1"><nlm:aff id="Aff4"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1937 1151</institution-id><institution-id institution-id-type="GRID">grid.7836.a</institution-id><institution>Division of Clinical Pharmacology, Department of Medicine,</institution><institution>University of Cape Town,</institution></institution-wrap>Cape Town, South Africa</nlm:aff><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>Cape Town</wicri:regionArea></affiliation></author></analytic><series><title level="j">Malaria Journal</title><idno type="eISSN">1475-2875</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p id="Par1">The ability of <italic>Plasmodium falciparum</italic> parasites to develop resistance to widely used anti-malarials threatens malaria control and elimination efforts. Regular drug efficacy monitoring is essential for ensuring effective treatment policies. In low transmission settings where therapeutic efficacy studies are often not feasible, routine surveillance for molecular markers associated with anti-malarial resistance provides an alternative for the early detection of emerging resistance. Such a longitudinal survey of changes in the prevalence of selected molecular markers of resistance was conducted in the malaria-endemic regions of Mpumalanga Province, South Africa, where malaria elimination at a district-level is being pursued.</p></sec><sec><title>Methods</title><p id="Par2">Molecular analyses to determine the prevalence of alleles associated with resistance to lumefantrine (<italic>mdr</italic>86N, <italic>crt</italic>76K and <italic>mdr1</italic> copy number variation) and sulfadoxine–pyrimethamine (<italic>dhfr</italic> triple, <italic>dhps</italic> double, SP quintuple) were conducted between 2001 and 2018, while artemisinin resistance markers (<italic>kelch13</italic> mutations) were assessed only in 2018.</p></sec><sec><title>Results</title><p id="Par3">Parasite DNA was successfully amplified from 1667/2393 (70%) of malaria-positive rapid diagnostic tests routinely collected at primary health care facilities. No artemisinin resistance-associated <italic>kelch13</italic> mutations nor amplification of the <italic>mdr1</italic> gene copy number associated with lumefantrine resistance were observed. However, prevalence of both the <italic>mdr</italic>86N and <italic>crt</italic>76K alleles increased markedly over the study period, with all isolates collected in 2018 carrying these markers. SP quintuple mutation prevalence increased steadily from 14% in 2001 to 96% in 2018. Mixed alleles at any of the codons assessed were rare by 2018.</p></sec><sec><title>Conclusion</title><p id="Par4">No <italic>kelch13</italic> mutations confirmed or suspected to be associated with artemisinin resistance were identified in 2018. Although parasites carrying the <italic>mdr</italic>86N and <italic>crt</italic>76K alleles associated with reduced lumefantrine susceptibility were strongly selected for over the study period, nearing fixation by 2018, the marker for lumefantrine resistance, namely increased <italic>mdr1</italic> copy number, was not observed in this study. The increase in <italic>mdr</italic>86N and <italic>crt</italic>76K allele prevalence together with intense regional artemether–lumefantrine drug pressure, raises concern regarding the sustained artemether–lumefantrine efficacy. Regular, rigorous anti-malarial resistance marker surveillance across all three South African malaria-endemic provinces to inform case management is recommended.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Baker, L" uniqKey="Baker L">L Baker</name></author><author><name sortKey="Barnes, K" uniqKey="Barnes K">K Barnes</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ukpe, Is" uniqKey="Ukpe I">IS Ukpe</name></author><author><name sortKey="Moonasar, D" uniqKey="Moonasar D">D Moonasar</name></author><author><name sortKey="Raman, J" uniqKey="Raman J">J Raman</name></author><author><name sortKey="Barnes, Ki" uniqKey="Barnes K">KI Barnes</name></author><author><name sortKey="Baker, L" uniqKey="Baker L">L Baker</name></author><author><name sortKey="Blumberg, L" uniqKey="Blumberg L">L Blumberg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Djimde, Aa" uniqKey="Djimde A">AA Djimde</name></author><author><name sortKey="Fofana, B" uniqKey="Fofana B">B Fofana</name></author><author><name sortKey="Sagara, I" uniqKey="Sagara I">I Sagara</name></author><author><name sortKey="Sidibe, B" uniqKey="Sidibe B">B Sidibe</name></author><author><name sortKey="Toure, S" uniqKey="Toure S">S Toure</name></author><author><name sortKey="Dembele, D" uniqKey="Dembele D">D Dembele</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Raman, J" uniqKey="Raman J">J Raman</name></author><author><name sortKey="Little, F" uniqKey="Little F">F Little</name></author><author><name sortKey="Roper, C" uniqKey="Roper C">C Roper</name></author><author><name sortKey="Kleinschmidt, I" uniqKey="Kleinschmidt I">I Kleinschmidt</name></author><author><name sortKey="Cassim, Y" uniqKey="Cassim Y">Y Cassim</name></author><author><name sortKey="Maharaj, R" uniqKey="Maharaj R">R Maharaj</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dondorp, Am" uniqKey="Dondorp A">AM Dondorp</name></author><author><name sortKey="Nosten, F" uniqKey="Nosten F">F Nosten</name></author><author><name sortKey="Yi, P" uniqKey="Yi P">P Yi</name></author><author><name sortKey="Das, D" uniqKey="Das D">D Das</name></author><author><name sortKey="Phyo, Ap" uniqKey="Phyo A">AP Phyo</name></author><author><name sortKey="Tarning, J" uniqKey="Tarning J">J Tarning</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tun, Km" uniqKey="Tun K">KM Tun</name></author><author><name sortKey="Imwong, M" uniqKey="Imwong M">M Imwong</name></author><author><name sortKey="Lwin, Km" uniqKey="Lwin K">KM Lwin</name></author><author><name sortKey="Win, Aa" uniqKey="Win A">AA Win</name></author><author><name sortKey="Hlaing, Tm" uniqKey="Hlaing T">TM Hlaing</name></author><author><name sortKey="Hlaing, T" uniqKey="Hlaing T">T Hlaing</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ashley, Ea" uniqKey="Ashley E">EA Ashley</name></author><author><name sortKey="Dhorda, M" uniqKey="Dhorda M">M Dhorda</name></author><author><name sortKey="Fairhurst, Rm" uniqKey="Fairhurst R">RM Fairhurst</name></author><author><name sortKey="Amaratunga, C" uniqKey="Amaratunga C">C Amaratunga</name></author><author><name sortKey="Lim, P" uniqKey="Lim P">P Lim</name></author><author><name sortKey="Suon, S" uniqKey="Suon S">S Suon</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Das, S" uniqKey="Das S">S Das</name></author><author><name sortKey="Saha, B" uniqKey="Saha B">B Saha</name></author><author><name sortKey="Hati, Ak" uniqKey="Hati A">AK Hati</name></author><author><name sortKey="Roy, S" uniqKey="Roy S">S Roy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lu, F" uniqKey="Lu F">F Lu</name></author><author><name sortKey="Culleton, R" uniqKey="Culleton R">R Culleton</name></author><author><name sortKey="Zhang, M" uniqKey="Zhang M">M Zhang</name></author><author><name sortKey="Ramaprasad, A" uniqKey="Ramaprasad A">A Ramaprasad</name></author><author><name sortKey="Von Seidlein, L" uniqKey="Von Seidlein L">L von Seidlein</name></author><author><name sortKey="Zhou, H" uniqKey="Zhou H">H Zhou</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sutherland, Cj" uniqKey="Sutherland C">CJ Sutherland</name></author><author><name sortKey="Lansdell, P" uniqKey="Lansdell P">P Lansdell</name></author><author><name sortKey="Sanders, M" uniqKey="Sanders M">M Sanders</name></author><author><name sortKey="Muwanguzi, J" uniqKey="Muwanguzi J">J Muwanguzi</name></author><author><name sortKey="Van Schalkwyk, Da" uniqKey="Van Schalkwyk D">DA van Schalkwyk</name></author><author><name sortKey="Kaur, H" uniqKey="Kaur H">H Kaur</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ikeda, M" uniqKey="Ikeda M">M Ikeda</name></author><author><name sortKey="Kaneko, M" uniqKey="Kaneko M">M Kaneko</name></author><author><name sortKey="Tachibane, S I" uniqKey="Tachibane S">S-I Tachibane</name></author><author><name sortKey="Balikagala, B" uniqKey="Balikagala B">B Balikagala</name></author><author><name sortKey="Sakurai Yatsushiro, M" uniqKey="Sakurai Yatsushiro M">M Sakurai-Yatsushiro</name></author><author><name sortKey="Yatsushiro, S" uniqKey="Yatsushiro S">S Yatsushiro</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Taylor, Sa" uniqKey="Taylor S">SA Taylor</name></author><author><name sortKey="Parobek, Cm" uniqKey="Parobek C">CM Parobek</name></author><author><name sortKey="Deconti, Dk" uniqKey="Deconti D">DK DeConti</name></author><author><name sortKey="Kayentao, K" uniqKey="Kayentao K">K Kayentao</name></author><author><name sortKey="Coulibaly, So" uniqKey="Coulibaly S">SO Coulibaly</name></author><author><name sortKey="Greenwood, Bm" uniqKey="Greenwood B">BM Greenwood</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Craig, Mh" uniqKey="Craig M">MH Craig</name></author><author><name sortKey="Kleinschmidt, I" uniqKey="Kleinschmidt I">I Kleinschmidt</name></author><author><name sortKey="Le Sueur, D" uniqKey="Le Sueur D">D le Sueur</name></author><author><name sortKey="Sharp, Bl" uniqKey="Sharp B">BL Sharp</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Raman, J" uniqKey="Raman J">J Raman</name></author><author><name sortKey="Mauff, K" uniqKey="Mauff K">K Mauff</name></author><author><name sortKey="Muiaga, P" uniqKey="Muiaga P">P Muiaga</name></author><author><name sortKey="Mussa, A" uniqKey="Mussa A">A Mussa</name></author><author><name sortKey="Maharaj, R" uniqKey="Maharaj R">R Maharaj</name></author><author><name sortKey="Barnes, Ki" uniqKey="Barnes K">KI Barnes</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mendez, F" uniqKey="Mendez F">F Mendez</name></author><author><name sortKey="Munoz, A" uniqKey="Munoz A">A Munoz</name></author><author><name sortKey="Carrasquilla, G" uniqKey="Carrasquilla G">G Carrasquilla</name></author><author><name sortKey="Jurado, D" uniqKey="Jurado D">D Jurado</name></author><author><name sortKey="Arevalo Herrera, M" uniqKey="Arevalo Herrera M">M Arevalo-Herrera</name></author><author><name sortKey="Cortese, Jf" uniqKey="Cortese J">JF Cortese</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Happi, Ct" uniqKey="Happi C">CT Happi</name></author><author><name sortKey="Gbotosho, Go" uniqKey="Gbotosho G">GO Gbotosho</name></author><author><name sortKey="Folarin, Oa" uniqKey="Folarin O">OA Folarin</name></author><author><name sortKey="Akinboye, Do" uniqKey="Akinboye D">DO Akinboye</name></author><author><name sortKey="Yusef, Bo" uniqKey="Yusef B">BO Yusef</name></author><author><name sortKey="Ebong, Oo" uniqKey="Ebong O">OO Ebong</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Djimde, A" uniqKey="Djimde A">A Djimde</name></author><author><name sortKey="Ogobara, K" uniqKey="Ogobara K">K Ogobara</name></author><author><name sortKey="Doumbo, Ok" uniqKey="Doumbo O">OK Doumbo</name></author><author><name sortKey="Cortese, Jf" uniqKey="Cortese J">JF Cortese</name></author><author><name sortKey="Kayentao, K" uniqKey="Kayentao K">K Kayentao</name></author><author><name sortKey="Doumbo, S" uniqKey="Doumbo S">S Doumbo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ariery, F" uniqKey="Ariery F">F Ariery</name></author><author><name sortKey="Witkowski, B" uniqKey="Witkowski B">B Witkowski</name></author><author><name sortKey="Amaratunga, C" uniqKey="Amaratunga C">C Amaratunga</name></author><author><name sortKey="Beghain, J" uniqKey="Beghain J">J Beghain</name></author><author><name sortKey="Langlois, A C" uniqKey="Langlois A">A-C Langlois</name></author><author><name sortKey="Khim, N" uniqKey="Khim N">N Khim</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Maharaj, R" uniqKey="Maharaj R">R Maharaj</name></author><author><name sortKey="Morris, N" uniqKey="Morris N">N Morris</name></author><author><name sortKey="Seocharan, I" uniqKey="Seocharan I">I Seocharan</name></author><author><name sortKey="Kruger, P" uniqKey="Kruger P">P Kruger</name></author><author><name sortKey="Moonasar, D" uniqKey="Moonasar D">D Moonasar</name></author><author><name sortKey="Mabuza, A" uniqKey="Mabuza A">A Mabuza</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Brooke, Bd" uniqKey="Brooke B">BD Brooke</name></author><author><name sortKey="Koekemoer, Ll" uniqKey="Koekemoer L">LL Koekemoer</name></author><author><name sortKey="Kruger, P" uniqKey="Kruger P">P Kruger</name></author><author><name sortKey="Urbach, J" uniqKey="Urbach J">J Urbach</name></author><author><name sortKey="Misiani, E" uniqKey="Misiani E">E Misiani</name></author><author><name sortKey="Coetzee, M" uniqKey="Coetzee M">M Coetzee</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Ngomane, L" uniqKey="Ngomane L">L Ngomane</name></author><author><name sortKey="De Jager, C" uniqKey="De Jager C">C de Jager</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Silal, Sp" uniqKey="Silal S">SP Silal</name></author><author><name sortKey="Little, F" uniqKey="Little F">F Little</name></author><author><name sortKey="Barnes, Ki" uniqKey="Barnes K">KI Barnes</name></author><author><name sortKey="White, Lj" uniqKey="White L">LJ White</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Govere, Jm" uniqKey="Govere J">JM Govere</name></author><author><name sortKey="La Grange, Jj" uniqKey="La Grange J">JJ La Grange</name></author><author><name sortKey="Durrheim, Dn" uniqKey="Durrheim D">DN Durrheim</name></author><author><name sortKey="Freese, Ja" uniqKey="Freese J">JA Freese</name></author><author><name sortKey="Sharp, Bl" uniqKey="Sharp B">BL Sharp</name></author><author><name sortKey="Mabuza, A" uniqKey="Mabuza A">A Mabuza</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Deacon, He" uniqKey="Deacon H">HE Deacon</name></author><author><name sortKey="Freese, Ja" uniqKey="Freese J">JA Freese</name></author><author><name sortKey="Sharp, Bl" uniqKey="Sharp B">BL Sharp</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mabuza, A" uniqKey="Mabuza A">A Mabuza</name></author><author><name sortKey="Govere, J" uniqKey="Govere J">J Govere</name></author><author><name sortKey="Grange, K" uniqKey="Grange K">K Grange</name></author><author><name sortKey="Mngomezulu, N" uniqKey="Mngomezulu N">N Mngomezulu</name></author><author><name sortKey="Allen, E" uniqKey="Allen E">E Allen</name></author><author><name sortKey="Zitha, A" uniqKey="Zitha A">A Zitha</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Barnes, Ki" uniqKey="Barnes K">KI Barnes</name></author><author><name sortKey="Durrheim, Dn" uniqKey="Durrheim D">DN Durrheim</name></author><author><name sortKey="Little, F" uniqKey="Little F">F Little</name></author><author><name sortKey="Jackson, A" uniqKey="Jackson A">A Jackson</name></author><author><name sortKey="Mehta, U" uniqKey="Mehta U">U Mehta</name></author><author><name sortKey="Allen, E" uniqKey="Allen E">E Allen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wooden, J" uniqKey="Wooden J">J Wooden</name></author><author><name sortKey="Keyes, S" uniqKey="Keyes S">S Keyes</name></author><author><name sortKey="Sibley, Ch" uniqKey="Sibley C">CH Sibley</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mangold, Ka" uniqKey="Mangold K">KA Mangold</name></author><author><name sortKey="Manson, Ru" uniqKey="Manson R">RU Manson</name></author><author><name sortKey="Koay, Esc" uniqKey="Koay E">ESC Koay</name></author><author><name sortKey="Stephens, L" uniqKey="Stephens L">L Stephens</name></author><author><name sortKey="Regner, M" uniqKey="Regner M">M Regner</name></author><author><name sortKey="Thomson, Rb" uniqKey="Thomson R">RB Thomson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Padley, D" uniqKey="Padley D">D Padley</name></author><author><name sortKey="Moody, Ah" uniqKey="Moody A">AH Moody</name></author><author><name sortKey="Chiodini, Pl" uniqKey="Chiodini P">PL Chiodini</name></author><author><name sortKey="Saldanha, J" uniqKey="Saldanha J">J Saldanha</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Plowe, Cv" uniqKey="Plowe C">CV Plowe</name></author><author><name sortKey="Cortese, Jf" uniqKey="Cortese J">JF Cortese</name></author><author><name sortKey="Djimde, A" uniqKey="Djimde A">A Djimde</name></author><author><name sortKey="Nwanyanwu, Oc" uniqKey="Nwanyanwu O">OC Nwanyanwu</name></author><author><name sortKey="Watkins, Wm" uniqKey="Watkins W">WM Watkins</name></author><author><name sortKey="Winstanley, Pa" uniqKey="Winstanley P">PA Winstanley</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sutherland, Cj" uniqKey="Sutherland C">CJ Sutherland</name></author><author><name sortKey="Haustein, T" uniqKey="Haustein T">T Haustein</name></author><author><name sortKey="Gadalla, N" uniqKey="Gadalla N">N Gadalla</name></author><author><name sortKey="Amstrong, M" uniqKey="Amstrong M">M Amstrong</name></author><author><name sortKey="Doherty, Jf" uniqKey="Doherty J">JF Doherty</name></author><author><name sortKey="Choidini, Pl" uniqKey="Choidini P">PL Choidini</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Price, Rn" uniqKey="Price R">RN Price</name></author><author><name sortKey="Uhlemann, Ac" uniqKey="Uhlemann A">AC Uhlemann</name></author><author><name sortKey="Brockman, A" uniqKey="Brockman A">A Brockman</name></author><author><name sortKey="Mcgready, R" uniqKey="Mcgready R">R McGready</name></author><author><name sortKey="Ashley, E" uniqKey="Ashley E">E Ashley</name></author><author><name sortKey="Phaipun, L" uniqKey="Phaipun L">L Phaipun</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Talundzic, E" uniqKey="Talundzic E">E Talundzic</name></author><author><name sortKey="Chenet, Sm" uniqKey="Chenet S">SM Chenet</name></author><author><name sortKey="Goldman, If" uniqKey="Goldman I">IF Goldman</name></author><author><name sortKey="Patel, Ds" uniqKey="Patel D">DS Patel</name></author><author><name sortKey="Nelson, Ja" uniqKey="Nelson J">JA Nelson</name></author><author><name sortKey="Plucinski, Mm" uniqKey="Plucinski M">MM Plucinski</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Brewer, Ca" uniqKey="Brewer C">CA Brewer</name></author><author><name sortKey="Pickle, L" uniqKey="Pickle L">L Pickle</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Harrower, M" uniqKey="Harrower M">M Harrower</name></author><author><name sortKey="Brewer, C" uniqKey="Brewer C">C Brewer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Okell, Lc" uniqKey="Okell L">LC Okell</name></author><author><name sortKey="Reiter, Lm" uniqKey="Reiter L">LM Reiter</name></author><author><name sortKey="Ebbe, Ls" uniqKey="Ebbe L">LS Ebbe</name></author><author><name sortKey="Baraka, V" uniqKey="Baraka V">V Baraka</name></author><author><name sortKey="Bisanzio, D" uniqKey="Bisanzio D">D Bisanzio</name></author><author><name sortKey="Watson, Oj" uniqKey="Watson O">OJ Watson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Venkatesan, M" uniqKey="Venkatesan M">M Venkatesan</name></author><author><name sortKey="Gadalla, Nb" uniqKey="Gadalla N">NB Gadalla</name></author><author><name sortKey="Stepniewska, K" uniqKey="Stepniewska K">K Stepniewska</name></author><author><name sortKey="Dahal, P" uniqKey="Dahal P">P Dahal</name></author><author><name sortKey="Nsanzabana, C" uniqKey="Nsanzabana C">C Nsanzabana</name></author><author><name sortKey="Moriera, C" uniqKey="Moriera C">C Moriera</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Malmberg, M" uniqKey="Malmberg M">M Malmberg</name></author><author><name sortKey="Ferreira, Pe" uniqKey="Ferreira P">PE Ferreira</name></author><author><name sortKey="Tarning, J" uniqKey="Tarning J">J Tarning</name></author><author><name sortKey="Ursing, J" uniqKey="Ursing J">J Ursing</name></author><author><name sortKey="Ngasala, B" uniqKey="Ngasala B">B Ngasala</name></author><author><name sortKey="Bjorkman, A" uniqKey="Bjorkman A">A Bjorkman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kublin, Jg" uniqKey="Kublin J">JG Kublin</name></author><author><name sortKey="Cortese, Jf" uniqKey="Cortese J">JF Cortese</name></author><author><name sortKey="Njunju, Em" uniqKey="Njunju E">EM Njunju</name></author><author><name sortKey="Makadam, Ra" uniqKey="Makadam R">RA Makadam</name></author><author><name sortKey="Wirima, Jj" uniqKey="Wirima J">JJ Wirima</name></author><author><name sortKey="Kazembe, Pn" uniqKey="Kazembe P">PN Kazembe</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Davlantes, E" uniqKey="Davlantes E">E Davlantes</name></author><author><name sortKey="Dimbu, Pr" uniqKey="Dimbu P">PR Dimbu</name></author><author><name sortKey="Ferreira, Cm" uniqKey="Ferreira C">CM Ferreira</name></author><author><name sortKey="Joao, Mf" uniqKey="Joao M">MF Joao</name></author><author><name sortKey="Pode, D" uniqKey="Pode D">D Pode</name></author><author><name sortKey="Felix, J" uniqKey="Felix J">J Felix</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Plucinski, Mm" uniqKey="Plucinski M">MM Plucinski</name></author><author><name sortKey="Dimbu, Pr" uniqKey="Dimbu P">PR Dimbu</name></author><author><name sortKey="Macaia, Ap" uniqKey="Macaia A">AP Macaia</name></author><author><name sortKey="Ferreira, Cm" uniqKey="Ferreira C">CM Ferreira</name></author><author><name sortKey="Samutondo, C" uniqKey="Samutondo C">C Samutondo</name></author><author><name sortKey="Quivinja, J" uniqKey="Quivinja J">J Quivinja</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Raman, J" uniqKey="Raman J">J Raman</name></author><author><name sortKey="Allen, E" uniqKey="Allen E">E Allen</name></author><author><name sortKey="Workman, L" uniqKey="Workman L">L Workman</name></author><author><name sortKey="Mabuza, A" uniqKey="Mabuza A">A Mabuza</name></author><author><name sortKey="Swanepoel, H" uniqKey="Swanepoel H">H Swanepoel</name></author><author><name sortKey="Malatje, G" uniqKey="Malatje G">G Malatje</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vaughan Williams, Ch" uniqKey="Vaughan Williams C">CH Vaughan-Williams</name></author><author><name sortKey="Raman, J" uniqKey="Raman J">J Raman</name></author><author><name sortKey="Raswiswi, E" uniqKey="Raswiswi E">E Raswiswi</name></author><author><name sortKey="Immelman, E" uniqKey="Immelman E">E Immelman</name></author><author><name sortKey="Reichel, H" uniqKey="Reichel H">H Reichel</name></author><author><name sortKey="Gates, K" uniqKey="Gates K">K Gates</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Artimovich, E" uniqKey="Artimovich E">E Artimovich</name></author><author><name sortKey="Kapito Tembo, A" uniqKey="Kapito Tembo A">A Kapito-Tembo</name></author><author><name sortKey="Pensulo, P" uniqKey="Pensulo P">P Pensulo</name></author><author><name sortKey="Nyirenda, O" uniqKey="Nyirenda O">O Nyirenda</name></author><author><name sortKey="Brown, S" uniqKey="Brown S">S Brown</name></author><author><name sortKey="Joshi, S" uniqKey="Joshi S">S Joshi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="White, Nj" uniqKey="White N">NJ White</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ishengoma, Ds" uniqKey="Ishengoma D">DS Ishengoma</name></author><author><name sortKey="Lwitiho, S" uniqKey="Lwitiho S">S Lwitiho</name></author><author><name sortKey="Madebe, Ra" uniqKey="Madebe R">RA Madebe</name></author><author><name sortKey="Nyagonde, N" uniqKey="Nyagonde N">N Nyagonde</name></author><author><name sortKey="Persson, O" uniqKey="Persson O">O Persson</name></author><author><name sortKey="Vestergaard, Ls" uniqKey="Vestergaard L">LS Vestergaard</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Papa Mze, N" uniqKey="Papa Mze N">N Papa Mze</name></author><author><name sortKey="Ndiaye, Yd" uniqKey="Ndiaye Y">YD Ndiaye</name></author><author><name sortKey="Diedhiou, Ck" uniqKey="Diedhiou C">CK Diedhiou</name></author><author><name sortKey="Rahamatou, D" uniqKey="Rahamatou D">D Rahamatou</name></author><author><name sortKey="Dieye, B" uniqKey="Dieye B">B Dieye</name></author><author><name sortKey="Daniels, Rf" uniqKey="Daniels R">RF Daniels</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ndiaye, M" uniqKey="Ndiaye M">M Ndiaye</name></author><author><name sortKey="Sow, D" uniqKey="Sow D">D Sow</name></author><author><name sortKey="Nag, S" uniqKey="Nag S">S Nag</name></author><author><name sortKey="Sylla, K" uniqKey="Sylla K">K Sylla</name></author><author><name sortKey="Tine, Rc" uniqKey="Tine R">RC Tine</name></author><author><name sortKey="Ndiaye, Jl" uniqKey="Ndiaye J">JL Ndiaye</name></author></analytic></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Afrique du Sud</li><li>Luxembourg (pays)</li><li>Thaïlande</li></country></list><tree><noCountry><name sortKey="Malatje, Gillian" sort="Malatje, Gillian" uniqKey="Malatje G" first="Gillian" last="Malatje">Gillian Malatje</name></noCountry><country name="Afrique du Sud"><noRegion><name sortKey="Raman, Jaishree" sort="Raman, Jaishree" uniqKey="Raman J" first="Jaishree" last="Raman">Jaishree Raman</name></noRegion><name sortKey="Barnes, Karen I" sort="Barnes, Karen I" uniqKey="Barnes K" first="Karen I." last="Barnes">Karen I. Barnes</name><name sortKey="Frean, John" sort="Frean, John" uniqKey="Frean J" first="John" last="Frean">John Frean</name><name sortKey="Kagoro, Frank M" sort="Kagoro, Frank M" uniqKey="Kagoro F" first="Frank M." last="Kagoro">Frank M. Kagoro</name><name sortKey="Mabuza, Aaron" sort="Mabuza, Aaron" uniqKey="Mabuza A" first="Aaron" last="Mabuza">Aaron Mabuza</name><name sortKey="Raman, Jaishree" sort="Raman, Jaishree" uniqKey="Raman J" first="Jaishree" last="Raman">Jaishree Raman</name></country><country name="Thaïlande"><noRegion><name sortKey="Kagoro, Frank M" sort="Kagoro, Frank M" uniqKey="Kagoro F" first="Frank M." last="Kagoro">Frank M. Kagoro</name></noRegion></country><country name="Luxembourg (pays)"><noRegion><name sortKey="Reid, Anthony" sort="Reid, Anthony" uniqKey="Reid A" first="Anthony" last="Reid">Anthony Reid</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000B21 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000B21 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= ChloroquineV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:6704579
|texte= Absence of kelch13 artemisinin resistance markers but strong selection for lumefantrine-tolerance molecular markers following 18 years of artemisinin-based combination therapy use in Mpumalanga Province, South Africa (2001–2018)
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:31438951" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a ChloroquineV1
| This area was generated with Dilib version V0.6.33. |  |